Takeaway
Age, sex and gene variants are correlated with different motor and cognitive phenotypes of amyloid lateral sclerosis (ALS).
Why this matters
ALS is a neurodegenerative disease that is complex due to the heterogeneity of its phenotype, which has both motor and cognitive components.
The identification of factors that modify ALS phenotype may help to reclassify patients into more pathogenically meaningful subgroups for targeted personalized therapy.