Genetics may influence the course of frontotemporal dementia


  • Mutations in the microtubule associated protein tau gene (MAPT) significantly influences age at onset and at death for individuals with frontotemporal dementia.

Why this matters

  • Frontotemporal dementia is a genetically and pathologically heterogeneous disease that is associated with behavioral and executive dysfunction; one third of cases are genetic.

  • Although the clinical features of these genetic forms of frontotemporal dementia are well characterized, the genetic link with age of onset and disease duration still requires clarification.