Takeaway
Carriers of the migraine risk allele, TRPM8 rs10166942, have a predisposition to migraine chronification.
Why this matters
This is the first study to demonstrate that the migraine risk allele, TRPM8 rs10166942, increases susceptibility to migraine chronification. Further investigation into the role of TRPM8 in allodynia pathogenesis and migraine chronification could lead to novel treatments.