White matter hyperintensities as a biomarker for cognitive decline in midlife


  • White matter hyperintensities (WMH) grow during the aging process and therefore may be useful biomarkers to identify middle-aged people who are at high risk for dementia with cognitive decline in the future.

Why this matters

  • Biomarkers are important tools to identify individuals at risk for dementia early on so interventions can be used to improve clinical outcomes, including cognitive function.

  • WMH are a potential biomarker of cognitive decline in dementia, however, they have not been studied in mid-life populations.